History of Science and Engineering Annotation << Back REVIEW OF SIGNIFICANT GENOME MODIFICATIONS CAUSE OF THE NEW CORONAVIRUS INFECTIONS (HISTORICAL REVIEW) A.A. Kornilova, S.N. Gaydamaka, M.A. Gladchenko, D.Ya. Agasarov, I.V. Kornilov, M.A. Gerasimov This review presents an analysis of studies on several of the most signifi cant strains of SARS-CoV-2 and the mutations associated with their occurrence. Modifi cations to the genome of the SARS-CoV-2 virus ensured the global spread of new strains and the adaptation of the virus to the immunized organism. The severe course of SARS-CoV-2 infection probably does not contribute to its rapid spread, and as a result, the most contagious strain becomes dominant, while at the same time causing mild or subtle symptoms in the host organism. Keywords: coronavirus, genome, strains, mutations. DOI: 10.25791/intstg.5.2022.1352 Pp. 03-11.